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Repulsive guidance molecule B (RGMB) plays negative roles in breast cancer by coordinating BMP signaling

Li, Jin, Ye, Lin, Sanders, Andrew James and Jiang, Wen Guo 2012. Repulsive guidance molecule B (RGMB) plays negative roles in breast cancer by coordinating BMP signaling. Journal of Cellular Biochemistry 113 (7) , pp. 2523-2531. 10.1002/jcb.24128

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Abstract

Repulsive guidance molecules (RGMs) coordinate axon formation and iron homestasis. These molecules are also known as co-receptors of bone morphogenetic proteins (BMPs). However, the role played by RGMs in breast cancer remains unclear. The present study investigated the impact of RGMB on functions of breast cancer cells and corresponding mechanisms. RGMB was knocked down in breast cancer cells by way of an anti-RGMB ribozyme transgene. Knockdown of RGMB resulted in enhanced capacities of proliferation, adhesion, and migration in breast cancer cells. Further investigations demonstrated RGMB knockdown resulted in a reduced expression and activity of Caspase-3, accompanied with better survival in RGMB knockdown cells under serum starvation, which might be induced by its repression on MAPK JNK pathway. Up-regulations of Snai1, Twist, FAK, and Paxillin via enhanced Smad dependent sigaling led to increased capacities of adhesion and migration. Our current data firstly revealed that RGMB may act as a negative regulator in breast cancer through BMP signaling.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Uncontrolled Keywords: RGM; BMP; breast cancer; apoptosis; focal adhesion; EMT; SMAD; MAPK
Publisher: John Wiley & Sons
ISSN: 0730-2312
Last Modified: 04 Jun 2017 04:35
URI: http://orca-mwe.cf.ac.uk/id/eprint/41411

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