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Immunogenicity and efficacy of an anthrax/plague DNA fusion vaccine in a mouse model

Albrecht, M. T., Eyles, J. E., Baillie, Les and Keane-Myers, A. M. 2012. Immunogenicity and efficacy of an anthrax/plague DNA fusion vaccine in a mouse model. FEMS Immunology & Medical Microbiology 65 (3) , pp. 505-509. 10.1111/j.1574-695X.2012.00974.x

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Abstract

The efficacy of multi-agent DNA vaccines consisting of a truncated gene encoding Bacillus anthracis lethal factor (LFn) fused to either Yersinia pestis V antigen (V) or Y. pestis F1 was evaluated. A/J mice were immunized by gene gun and developed predominantly IgG1 responses that were fully protective against a lethal aerosolized B. anthracis spore challenge but required the presence of an additional DNA vaccine expressing anthrax protective antigen to boost survival against aerosolized Y. pestis.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Subjects: Q Science > QR Microbiology > QR180 Immunology
R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords: anthrax; plague; DNA vaccine
Publisher: Wiley-Blackwell
ISSN: 1574-695X
Last Modified: 04 Jun 2017 04:32
URI: http://orca-mwe.cf.ac.uk/id/eprint/40632

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