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Synthesis and Antimicrobial Activities of Novel Series of Heterocyclic α-Aminophosphonates

Abdel-Megeed, Mohamed F., Badr, Badr E., Azaam, Mohamed M. and El-Hiti, Gamal A. 2012. Synthesis and Antimicrobial Activities of Novel Series of Heterocyclic α-Aminophosphonates. Archiv der Pharmazie 345 (10) , pp. 784-789. 10.1002/ardp.201200109

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Abstract

Two series of novel α-aminophosphonates having heterocyclic moieties have been synthesized in high yields. The structures of the newly synthesized compounds were confirmed by their elemental analyses, IR, 1H NMR and MS spectral data. These compounds were screened for their antibacterial activities against Escherichia coli (NCIM2065), as a Gram-negative bacterium, Bacillus subtilis (PC1219) and Staphylococcus aureus (ATCC25292), as Gram-positive bacteria, and Candida albicans and Schccaromycies cerevisiae as fungi. The minimum inhibitory concentrations (MICs) of the synthesized compounds show high antibacterial and antifungal activities at low concentrations (10-1000 μg/mL). Furthermore, their lethal doses indicated that such compounds are safe for use.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Subjects: Q Science > QD Chemistry
Uncontrolled Keywords: α-Aminophosphonates; 2-Amino-4-chloro-6-methylpyrimidine; 3-Aminoquinazolin-4(3H)-one; Antimicrobial activities; Lethal dose
Publisher: Wiley-Blackwell
ISSN: 0365-6233
Last Modified: 19 Mar 2016 23:05
URI: http://orca-mwe.cf.ac.uk/id/eprint/38158

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