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Conventional versus hypofractionated high-dose intensity-modulated radiotherapy for prostate cancer: Preliminary safety results from the CHHiP randomised controlled trial

Dearnaley, David, Syndikus, Isabel, Sumo, Georges, Bidmead, Margaret, Bloomfield, David, Clark, Catharine, Gao, Annie, Hassan, Shama, Horwich, Alan, Huddart, Robert, Khoo, Vincent, Kirkbride, Peter, Mayles, Helen, Mayles, Philip, Naismith, Olivia, Parker, Chris, Patterson, Helen, Russell, Martin, Scrase, Christopher, South, Chris, Staffurth, John Nicholas and Hall, Emma 2012. Conventional versus hypofractionated high-dose intensity-modulated radiotherapy for prostate cancer: Preliminary safety results from the CHHiP randomised controlled trial. The Lancet Oncology 13 (1) , pp. 43-54. 10.1016/S1470-2045(11)70293-5

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Abstract

Background: Prostate cancer might have high radiation-fraction sensitivity, implying a therapeutic advantage of hypofractionated treatment. We present a pre-planned preliminary safety analysis of side-effects in stages 1 and 2 of a randomised trial comparing standard and hypofractionated radiotherapy. Methods: We did a multicentre, randomised study and recruited men with localised prostate cancer between Oct 18, 2002, and Aug 12, 2006, at 11 UK centres. Patients were randomly assigned in a 1:1:1 ratio to receive conventional or hypofractionated high-dose intensity-modulated radiotherapy, and all were given with 3–6 months of neoadjuvant androgen suppression. Computer-generated random permuted blocks were used, with risk of seminal vesicle involvement and radiotherapy-treatment centre as stratification factors. The conventional schedule was 37 fractions of 2 Gy to a total of 74 Gy. The two hypofractionated schedules involved 3 Gy treatments given in either 20 fractions to a total of 60 Gy, or 19 fractions to a total of 57 Gy. The primary endpoint was proportion of patients with grade 2 or worse toxicity at 2 years on the Radiation Therapy Oncology Group (RTOG) scale. The primary analysis included all patients who had received at least one fraction of radiotherapy and completed a 2 year assessment. Treatment allocation was not masked and clinicians were not blinded. Stage 3 of this trial completed the planned recruitment in June, 2011. This study is registered, number ISRCTN97182923. Findings: 153 men recruited to stages 1 and 2 were randomly assigned to receive conventional treatment of 74 Gy, 153 to receive 60 Gy, and 151 to receive 57 Gy. With 50·5 months median follow-up (IQR 43·5–61·3), six (4·3%; 95% CI 1·6–9·2) of 138 men in the 74 Gy group had bowel toxicity of grade 2 or worse on the RTOG scale at 2 years, as did five (3·6%; 1·2–8·3) of 137 men in the 60 Gy group, and two (1·4%; 0·2–5·0) of 143 men in the 57 Gy group. For bladder toxicities, three (2·2%; 0·5–6·2) of 138 men, three (2·2%; 0·5–6·3) of 137, and none (0·0%; 97·5% CI 0·0–2·6) of 143 had scores of grade 2 or worse on the RTOG scale at 2 years. Interpretation: Hypofractionated high-dose radiotherapy seems equally well tolerated as conventionally fractionated treatment at 2 years

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Additional Information: Stage 1 was funded by the Academic Radiotherapy Unit, Cancer Research UK programme grant; Stage 2 was funded by the Department of Health and Cancer Research UK.
Publisher: Elsevier
ISSN: 1470-2045
Funders: Academic Radiotherapy Unit, Cancer Research UK, Department of Health
Date of First Compliant Deposit: 15 October 2018
Last Modified: 15 Oct 2018 10:59
URI: http://orca-mwe.cf.ac.uk/id/eprint/37544

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