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Aequorea victoria bioluminescence moves into an exciting new era

Kendall, Jonathan M. and Badminton, Michael Norman 1998. Aequorea victoria bioluminescence moves into an exciting new era. Trends in Biotechnology 16 (5) , pp. 216-224. 10.1016/S0167-7799(98)01184-6

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Bioluminescence has revolutionized research into many cellular and molecular-biological processes, ranging from intracellular signalling to gene transcription. This article focuses on the chemistry and biotechnological exploitation of the two proteins involved in bioluminescence of the jellyfish Aequoreavictoria—aequorin and green fluorescent protein. Engineered recombinant aequorin has led to a novel technological approach to monitoring calcium signals in organelles and subcellular domains. A new generation of intracellular calcium indicators has been produced in which engineered variants of green fluorescent protein are used to probe their ionic environment using intramolecular fluorescence-resonance-energy transfer.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: bioluminescence; green fluorescent protein; FRET; aequorin; intracellular calcium;fluorescence-resonance-energy transfer
Publisher: Elsevier
ISSN: 0167-7799
Last Modified: 04 Jun 2017 04:20

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