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Cell-population tracking using quantum dots in flow cytometry

Summers, Huw D., Errington, Rachel Jane, Smith, Paul James, Chappell, Sally Claire, Rees, Paul, Brown, Martyn R. and Leary, James F. 2008. Cell-population tracking using quantum dots in flow cytometry. Presented at: Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications V, San Jose, CA, USA, 21-23 February 2008. Published in: Cartwright, A. N. and Nicolau, D. V. eds. Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications V. Proceedings of the SPIE , vol. 6865. Bellingham, WA: SPIE, 68650L. 10.1117/12.763602

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We have used flow-cytometry together with computational modeling of quantum dot portioning during cell division to identify population distributions of proliferating cells. The objective has been to develop a robust assay of integrated cellular fluorescence which reports the extent of cellular bifurcation within a complex population and potentially provides profiles of drug resistance, cell clonality and levels of aneuploidy in tumour cells. The implementation of a data analysis program based on genetic algorithms provides a complete description of the proliferation dynamics and gives values for the inter-mitotic time, the partitioning ratio of quantum dots between daughter cells and their associated deviations.

Item Type: Conference or Workshop Item (Paper)
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: Q Science > QH Natural history > QH301 Biology
R Medicine > R Medicine (General)
Publisher: SPIE
ISBN: 9780819470409
Last Modified: 04 Jun 2017 04:20

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