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Systemic photoprotection with alpha-tocopherol (vitamin E) and beta-carotene

Anstey, Alexander Vincent 2002. Systemic photoprotection with alpha-tocopherol (vitamin E) and beta-carotene. Clinical and Experimental Dermatology 27 (3) , pp. 170-176. 10.1046/j.1365-2230.2002.01040.x

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Cutaneous photodamage is partly mediated via oxidative pathways and there is evidence to suggest that antioxidants within the skin may have a photoprotective effect. Antioxidant activity is provided by a number of naturally occurring substances including alpha-tocopherol (vitamin E) and beta-carotene, whose effects are mediated by their capacity to quench singlet oxygen, scavenge free radicals and prevent the formation of free radicals. Beta-carotene has been used as treatment for various photosensitivity disorders for more than 30 years. The main indication for its use is in the treatment of the photosensitivity associated with erythropoietic protoporphyria. A role for beta-carotene in the prevention of non-melanoma skin cancer has yet to be demonstrated despite clinical research activity in this area. The role for alpha-tocopherol as a photoprotective agent is less clear-cut and it has yet to be established as treatment either for conditions characterized by photosensitivity or as an agent for preventing chronic photodamage or cutaneous malignancy.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
R Medicine > RL Dermatology
Publisher: Wiley-Blackwell
ISSN: 0307-6938
Last Modified: 19 Mar 2016 23:03

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