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Synthesis and biological evaluation of methylene-bridged analogs of the potent cannabinoid receptor antagonist rimonabant

Slusarczyk, Magdalena, De Borggraeve, Wim M., Hoornaert, Georges, Deroose, Frederik and Linders, Joannes T. M. 2008. Synthesis and biological evaluation of methylene-bridged analogs of the potent cannabinoid receptor antagonist rimonabant. European Journal of Organic Chemistry 2008 (8) , pp. 1350-1357. 10.1002/ejoc.200700960

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Abstract

Methylene-bridged analogs of rimonabant were synthesized and evaluated for their activity on CB1 receptors. The pyrazine derivative showed some activity as a CB1 antagonist.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Subjects: R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Uncontrolled Keywords: Heterocycles ; Cyclocondensation ; Diels–Alder reaction
Publisher: Wiley
ISSN: 1434-193X
Last Modified: 02 Apr 2019 14:36
URI: http://orca-mwe.cf.ac.uk/id/eprint/36853

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