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The role of inducible nitric oxide synthase in the host response to Coxsackievirus myocarditis

Zaragoza, Carlos, Ocampo, Christopher, Saura, Marta, Leppo, Michelle, Wei, Xiao-Qing, Quick, Richard, Moncada, Salvador, Liew, Foo Y. and Lowenstein, Charles J. 1998. The role of inducible nitric oxide synthase in the host response to Coxsackievirus myocarditis. Proceedings of the National Academy of Sciences of the United States of America 95 (5) , pp. 2469-2474.

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Abstract

The host response to Coxsackievirus infection is complex, including T lymphocytes, B lymphocytes, natural killer cells, and macrophages. Although Coxsackievirus infection induces expression of inducible nitric oxide synthase (NOS2; EC 1.14.13.39) in macrophages, the precise role of NOS2 in the host response to Coxsackievirus myocarditis has been unclear. We show, by using mice homozygous for a disrupted NOS2 allele, that Coxsackievirus replicates to higher titers in NOS22/2 mice, that the host lacking NOS2 clears virus more slowly than the wild-type host, and that myocarditis is much more severe in infected NOS22/2 mice. These data show that NOS2 is crucial for the host response to Coxsackievirus in the mouse.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Dentistry
Subjects: R Medicine > R Medicine (General)
Publisher: National Academy of Sciences
ISSN: 0027-8424
Last Modified: 04 Jun 2017 04:16
URI: http://orca-mwe.cf.ac.uk/id/eprint/35654

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