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Septic arthritis following Staphylococcus aureus infection in mice lacking inducible nitric oxide synthase

McInnes, Iain B., Leung, Bernard, Wei, Xiao-Qing, Gemmell, Curtis C. and Liew, Foo Y. 1998. Septic arthritis following Staphylococcus aureus infection in mice lacking inducible nitric oxide synthase. The Journal of Immunology 160 (1) , pp. 308-315.

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Abstract

Nitric oxide (NO), produced in large amounts by inducible NO synthase (iNOS), has emerged recently as an important microbicidal and immunomodulatory mediator. We have investigated its role in bacterial septic arthritis caused by Staphylococcus aureus infection using iNOS-deficient mice. The incidence, rate of development, and severity of arthritis were greater in iNOS-deficient than in heterozygous or wild-type control mice. Similarly, the incidence and severity of septicemia and mortality were significantly higher in iNOS-deficient mice compared with controls. Increased TNF-α synthesis in vivo and in vitro and enhanced IFN-γ compared with IL-4 production in vitro in iNOS-mutant mice demonstrated exaggerated Th1 polarization of the host response. These data indicate that high output NO production is not a prerequisite for severe articular destruction and imply that NO is of importance in synovial defense against staphylococcal infection.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Dentistry
Subjects: Q Science > QR Microbiology > QR180 Immunology
Publisher: American Association of Immunologists
ISSN: 0022-1767
Last Modified: 04 Jun 2017 04:16
URI: http://orca-mwe.cf.ac.uk/id/eprint/35653

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