Synthesis and in vitro evaluation of taxol oxetane ring D precursors

Kaspera, Rüdiger, Cape, Jonathan L., Faraldos, Juan A., Ketchum, Raymond E. B. and Croteau, Rodney B. 2010. Synthesis and in vitro evaluation of taxol oxetane ring D precursors. Tetrahedron Letters 51 (15) , pp. 2017-2019. 10.1016/j.tetlet.2010.02.033

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Abstract

A series of potential taxoid substrates was prepared in radiolabeled form to probe in vitro for the oxirane formation step and subsequent ring expansion step to the oxetane (ring D) presumably involved in the biosynthesis of the anticancer agent Taxol. None of the taxoid test substrates underwent transformation in cell-free systems from Taxus suggesting that these surrogates bore substitution patterns inappropriate for recognition or catalysis by the target enzymes, or that taxoid oxiranes and oxetanes arise by independent biosynthetic pathways.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Subjects:	Q Science > QD Chemistry
Publisher:	Elsevier
ISSN:	0040-4039
Last Modified:	23 Mar 2017 03:42
URI:	https://orca.cardiff.ac.uk/id/eprint/35621

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