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Evidence for striatal dopamine release during a video game [Letter]

Koepp, M. J., Gunn, R. N., Lawrence, Andrew David ORCID: https://orcid.org/0000-0001-6705-2110, Cunningham, V. J., Dagher, A., Jones, T., Brooks, D. J., Bench, C. J. and Grasby, P. M. 1998. Evidence for striatal dopamine release during a video game [Letter]. Nature 393 (6682) , pp. 266-268. 10.1038/30498

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Abstract

Dopaminergic neurotransmission may be involved in learning, reinforcement of behaviour, attention, and sensorimotor integration1,2. Binding of the radioligand 11C-labelled raclopride to dopamine D2 receptors is sensitive to levels of endogenous dopamine, which can be released by pharmacological challenge3, 4, 5, 6, 7, 8. Here we use 11C-labelled raclopride and positron emission tomography scans to provide evidence that endogenous dopamine is released in the human striatum during a goal-directed motor task, namely a video game. Binding of raclopride to dopamine receptors in the striatum was significantly reduced during the video game compared with baseline levels of binding, consistent with increased release and binding of dopamine to its receptors. The reduction in binding of raclopride in the striatum positively correlated with the performance level during the task and was greatest in the ventral striatum. These results show, to our knowledge for the first time, behavioural conditions under which dopamine is released in humans, and illustrate the ability of positron emission tomography to detect neurotransmitter fluxes in vivo during manipulations of behaviour.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Psychology
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: Nature Publishing Group
ISSN: 0028-0836
Last Modified: 21 Oct 2022 09:10
URI: https://orca.cardiff.ac.uk/id/eprint/35495

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