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T cell receptor-bearing cells among rat intestinal intraepithelial lymphocytes are mainly α/β+ and are thymus dependent

Vaage, John Torgils, Dissen, Erik, Ager, Ann, Roberts, Ian, Fossum, Sigbjørn and Rolstad, Bent 1990. T cell receptor-bearing cells among rat intestinal intraepithelial lymphocytes are mainly α/β+ and are thymus dependent. European Journal of Immunology 20 (5) , pp. 1193-1196. 10.1002/eji.1830200538

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Abstract

Rearrangement of both the β and γ chain T cell receptor (TcR) genes was detected in intestinal intraepithelial lymphocytes (IEL) from normal euthymic rats. Flow cytometric analyses showed that about 73% of the IEL were CD3+ (1F4) and that67% were TcR α/β+ (R73). About 5% of the IEL were found to be CD3+, TcR α/β− in double-labeling experiments suggesting that a small fraction of IEL in the rat express the alternative TcR γ/δ. More than 70% of the IEL were granular implying that many CD3+ IEL are granular. In IEL from athymic nude rats no rearrangement of either the TcR β or γ chain genes or surface expression of CD3 or TcR α/β was detected despite the fact that about 95% of the cells were granular and morphologically similar to those in normal rats. Taken together our data suggest that the majority of IEL in the rat express the conventional TcR α/β and that TcR-bearingcells in the gut epithelium are thymus dependent.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: Q Science > QR Microbiology > QR180 Immunology
Publisher: John Wiley & Sons
ISSN: 0014-2980
Last Modified: 04 Jun 2017 04:13
URI: http://orca-mwe.cf.ac.uk/id/eprint/34833

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