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RNA encoding the MPT83 antigen induces protective immune responses against Mycobacterium tuberculosis infection

Xue, Tian, Stavropoulos, Evangelos, Yang, Min, Ragno, Silvia, Vordermeier, Martin, Chambers, Mark, Hewinson, Glyn, Lowrie, Douglas Bruce, Colston, M. Joseph and Tascon, Ricardo E. 2004. RNA encoding the MPT83 antigen induces protective immune responses against Mycobacterium tuberculosis infection. Infection and Immunity 72 (11) , pp. 6324-9. 10.1128/IAI.72.11.6324-6329.2004

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Abstract

We have previously demonstrated that vaccination of mice with plasmid DNA vectors expressing immunodominant mycobacterial genes induced cellular immune responses and significant protection against challenge with Mycobacterium tuberculosis. We demonstrate here, using in vitro-synthesized RNA, that vaccination with DNA or RNA constructs expressing the M. tuberculosis MPT83 antigen are capable of inducing specific humoral and T-cell immune responses and confer modest but significant protection against M. tuberculosis challenge in mice. This is the first report of protective immunity conferred against intracellular bacteria by an RNA vaccine. This novel approach avoids some of the drawbacks of DNA vaccines and illustrates the potential for developing new antimycobacterial immunization strategies.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
ISSN: 00199567
Last Modified: 04 Jun 2017 01:31
URI: http://orca-mwe.cf.ac.uk/id/eprint/346

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