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In vitro susceptibility of oral Candida to seven antifungal agents

Kuriyama, Tomoari, Williams, David Wynne, Bagg, J., Coulter, W. A., Ready, D. and Lewis, Michael Alexander Oxenham 2005. In vitro susceptibility of oral Candida to seven antifungal agents. Oral Microbiology and Immunology 20 (6) , pp. 349-353. 10.1111/j.1399-302X.2005.00236.x

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Abstract

The in vitro susceptibility of 618 Candida isolates to fluconazole, itraconazole, voriconazole, ketoconazole, miconazole, amphotericin B, and nystatin was determined. The isolates were obtained from 559 patients who had attended the UK dental hospital departments in Cardiff, Belfast, Glasgow or London. Antifungal susceptibility was assessed using a broth microdilution method following the National Committee for Clinical Laboratory Standards (NCCLS) M27-A guidelines. The majority of the test strains were C. albicans (n = 521) with few of these being resistant to fluconazole (0.3%). A low incidence of fluconazole resistance (0–6.8%) was similarly evident with all non albicans species (Candida glabrata, 5 of 59 resistant; Candida krusei, 0 of 7 resistant; Candida tropicalis, 0 of 13 resistant; Candida parapsilosis, 0 of 12 resistant; other Candida species, 0 of 6 resistant). Voriconazole, ketoconazole, and miconazole also revealed high activity against both C. albicans and non albicans isolates, and 23.7% of C. glabrata isolates were found to be resistant to itraconazole. There was little difference in the antifungal susceptibilities of Candida isolated from patients who had a history of previous antifungal therapy compared with those who had not received antifungal treatment. In summary, this surveillance study of antifungal susceptibility of oral candidal isolates in the UK, through the collaboration of four dental hospitals, demonstrates that oral Candida species have a high level of susceptibilities to a range of antifungal agents.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Dentistry
Subjects: Q Science > QR Microbiology
R Medicine > RK Dentistry
Uncontrolled Keywords: antifungal agent; antifungal susceptibility; Candida; in vitro activity; oral disease
Publisher: Wiley
ISSN: 0902-0055
Last Modified: 09 Jun 2019 22:20
URI: http://orca-mwe.cf.ac.uk/id/eprint/34550

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