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Cyclosporine in severe childhood atopic dermatitis: a multicenter study

Berth-Jones, J., Finlay, Andrew Yule, Zaki, I., Tan, B., Goodyear, H., Lewis-Jones, S, Cork, M. J., Bleehen, S. S, Salek, Mir-saeed, Allen, B. R., Friedmann, P., Harper, J., Camp, R. D. R., Smith, S. and Graham-Brown, R. A. C. 1996. Cyclosporine in severe childhood atopic dermatitis: a multicenter study. Journal of the American Academy of Dermatology 34 (6) , pp. 1016-1021. 10.1016/S0190-9622(96)90281-9,

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Abstract

Background:Severeatopic dermatitis (AD) remains difficult to treat. Cyclosporine is effective in adults but has not previously been investigated in children with AD. Objective: The aims were to investigate the efficacy, safety, and tolerability of cyclosporine in severe refractory childhood AD. Methods: Subjects 2 to 16 years of age were treated for 6 weeks with cyclosporine, 5 mg/kg per day, in an open study. Disease activity was monitored every 2 weeks by means of sign scores, visual analogue scales for symptoms, and quality-of-life questionnaires. Adverse events were monitored. Efficacy and tolerability were assessed with five-point scales. Results: Twenty-seven children were treated. Significant improvements were seen in all measures of disease activity. Twenty-two showed marked improvement or total clearing. Quality of life improved for both the children and their families. Tolerability was considered good or very good in 25 subjects. Conclusion:Cyclosporine may offer an effective, safe, and well-tolerated short-term treatment option for children with severe AD.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Pharmacy
Subjects: R Medicine > RL Dermatology
R Medicine > RM Therapeutics. Pharmacology
Publisher: Elsevier Health
ISSN: 0190-9622
Last Modified: 04 Jun 2017 04:11
URI: http://orca-mwe.cf.ac.uk/id/eprint/34221

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