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Prefrontal-subcortical dissociations underlying inhibitory control revealed by event-related fMRI

Kelly, A. M. Clare, Hester, Robert, Murphy, Kevin, Javitt, Daniel C., Foxe, John J. and Garavan, Hugh 2004. Prefrontal-subcortical dissociations underlying inhibitory control revealed by event-related fMRI. European Journal of Neuroscience 19 (11) , pp. 3105-3112. 10.1111/j.0953-816X.2004.03429.x

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Using event-related fMRI, this study investigated the neural dynamics of response inhibition under fluctuating task demands. Fourteen participants performed a GO/NOGO task requiring inhibition of a prepotent motor response to NOGO events that occurred as part of either a Fast or Slow presentation stream of GO stimuli. We compared functional activations associated with correct withholds (Stops) required during the Fast presentation stream of stimuli to Stops required during the Slow presentation stream. A predominantly right hemispheric network was activated across conditions, consistent with previous studies. Furthermore, a functional dissociation of activations between conditions was observed. Slow Stops elicited additional activation in anterior dorsal and polar prefrontal cortex and left inferior parietal cortex. Fast Stops showed additional activation in a network that included right dorsolateral prefrontal cortex, insula and dorsal striatum. These results are discussed in terms of our understanding of the impact of preparation on the distributed network underlying response inhibition and the contribution of subcortical areas, such as the basal ganglia, to executive control processes.

Item Type: Article
Status: Published
Schools: Psychology
Physics and Astronomy
Cardiff University Brain Research Imaging Centre (CUBRIC)
Uncontrolled Keywords: basal ganglia; executive functions; functional neuroimaging; inhibition; prefrontal cortex
ISSN: 0953-816X
Last Modified: 08 May 2019 14:04

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