Sensory preconditioning in rats with lesions of the anterior thalamic nuclei: evidence for intact nonspatial 'relational' processing

Ward-Robinson, Jasper, Wilton, L. A. K., Muir, Janice L., Honey, Robert Colin ORCID: https://orcid.org/0000-0001-6870-1880, Vann, Seralynne Denise ORCID: https://orcid.org/0000-0002-6709-8773 and Aggleton, John Patrick ORCID: https://orcid.org/0000-0002-5573-1308 2002. Sensory preconditioning in rats with lesions of the anterior thalamic nuclei: evidence for intact nonspatial 'relational' processing. Behavioural Brain Research 133 (2) , pp. 125-133. 10.1016/S0166-4328(01)00465-X

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Abstract

Rats with neurotoxic lesions centered in the anterior thalamic nuclei were trained in two versions of a nonspatial, sensory preconditioning procedure. In both versions, two stimulus compounds (AX and BY) were first presented and then X, but not Y, was paired with an aversive unconditioned stimulus. This procedure resulted in greater conditioned responding to A than B. Anterior thalamic lesions had no apparent effect on these two examples of sensory preconditioning, nor did they affect fear conditioning or conditioned taste aversion. In contrast, the same lesions led to a severe deficit on a test of spatial memory. These results help to refine our understanding of the contribution of the anterior thalamic nuclei to spatial memory.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	Anterior thalamic nuclei; Spatial memory; Nonspatial memory; Sensory preconditioning; Aversive conditioning; Hippocampus
Publisher:	Elsevier
ISSN:	0166-4328
Last Modified:	07 Nov 2023 11:17
URI:	https://orca.cardiff.ac.uk/id/eprint/33245

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