Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Functional anatomy of the therapeutic effects of prism adaptation on left neglect

Luaute, J., Michel, C., Rode, G., Pisella, L., Jacquin-Courtois, S., Costes, N., Cotton, F., le Bars, D., Boisson, D., Halligan, Peter and Rossetti, Y. 2006. Functional anatomy of the therapeutic effects of prism adaptation on left neglect. Neurology 66 (12) , pp. 1859-1867. 10.1212/01.wnl.0000219614.33171.01

Full text not available from this repository.

Abstract

Objective: To investigate the anatomic substrates underlying the beneficial effect of prism adaptation in five patients with persistent left neglect following right stroke. Methods: In a functional imaging PET study, we used a covariation analysis to examine linear changes of regional cerebral blood flow over sessions as a function of left neglect improvement. Results: The network of significant brain regions associated with improvement of left neglect performance produced by prism adaptation involved the right cerebellum, the left thalamus, the left temporo-occipital cortex, the left medial temporal cortex, and the right posterior parietal cortex. Conclusion: Our results suggest that the realignment of visuomotor coordinates is processed by the cerebellum and that low level sensorimotor adaptation actively modulates cerebral areas, albeit now relying on intact cerebellocerebral connections. Hence, our data support the hypothesis that the beneficial effect of prism adaptation on the clinical presentation of left neglect derives from modulation of cortical regions implicated in spatial cognition.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Psychology
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: American Academy of Neurology
ISSN: 0028-3878
Last Modified: 04 Jun 2017 04:07
URI: http://orca-mwe.cf.ac.uk/id/eprint/33055

Citation Data

Cited 97 times in Google Scholar. View in Google Scholar

Cited 93 times in Scopus. View in Scopus. Powered By Scopus® Data

Cited 72 times in Web of Science. View in Web of Science.

Actions (repository staff only)

Edit Item Edit Item