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Context- but not familiarity-dependent forms of object recognition are impaired following excitotoxic hippocampal lesions in rats

Good, Mark Andrew, Barnes, Philip Andrew, Staal, Victoria Ann, McGregor, Anthony and Honey, Robert Colin 2007. Context- but not familiarity-dependent forms of object recognition are impaired following excitotoxic hippocampal lesions in rats. Behavioral Neuroscience 121 (1) , pp. 218-223. 10.1037/0735-7044.121.1.218

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Abstract

Dual-process models of recognition memory in animals propose that recognition memory is supported by two independent processes that reflect the operation of distinct brain structures: a familiarity process that operates independently of the hippocampus and a context-dependent (episodic) memory process that is dependent on the hippocampus. A novel variant of an object recognition procedure was used to examine this proposal. Healthy rats showed a preference for exploring a novel object rather than a familiar object: a familiarity-dependent recognition effect. They also showed a preference for exploring a familiar object that was presented in a different spatiotemporal context rather than a familiar object that was presented either in a different spatial or temporal context: a context-dependent form of recognition that is sensitive to "what" object has been presented "where" and "when." Rats with excitotoxic hippocampal lesions showed the familiarity-dependent but not the context-dependent form of recognition. The results provide support for dual-process theories of recognition memory.

Item Type: Article
Status: Published
Schools: Psychology
Publisher: American Psychological Association
ISSN: 1939-0084
Last Modified: 23 Aug 2017 02:45
URI: http://orca-mwe.cf.ac.uk/id/eprint/33042

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Cited 71 times in Scopus. View in Scopus. Powered By Scopus® Data

Cited 61 times in Web of Science. View in Web of Science.

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