Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

A diffusion tensor magnetic resonance imaging study of frontal cortex connections in very late-onset schizophrenia-like psychosis

Jones, Derek K., Catani, M., Pierpaoli, C., Reeves, S. J., Shergill, S. S., O'Sullivan, Michael, Maguire, P., Horsfield, M. A., Simmons, A., Williams, S. C. and Howard, R. J. 2005. A diffusion tensor magnetic resonance imaging study of frontal cortex connections in very late-onset schizophrenia-like psychosis. American Journal of Geriatric Psychiatry 13 (12) , pp. 1092-1099.

Full text not available from this repository.


Objective: Onset of psychosis after the age of 60 may be associated with structural abnormalities within cerebral white matter. The authors looked within white-matter tracts, which mediate connectivity of the frontal lobes, in psychotic patients for evidence of loss of fiber integrity consistent with degenerative damage. Methods: Fourteen patients with very-late-onset schizophrenia-like psychosis and an age-matched control group underwent diffusion tensor magnetic resonance imaging. Tract maps were constructed for each subject from the imaging data, and measurements of fractional anisotropy and mean diffusivity were made within the uncinate, superior longitudinal, and inferior occipito-frontal fasciculi, and the cingulum. Results: There were no significant differences in fractional anisotropy, a measure of the ordering of axons within fiber tracts, nor in mean diffusivity, an orientationally-averaged measure of the bulk diffusivity within each voxel, between patients and control subjects. Conclusion: The lack of difference in fractional anisotropy and mean diffusivity measures between patients and controls argues against the presence of structural abnormalities within these tracts and the notion that a focal white-matter abnormality within the tracts investigated underpins the onset of psychosis.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Psychology
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: Lippincott Williams & Wilkins
ISSN: 1064-7481
Last Modified: 04 Jun 2017 04:07

Citation Data

Cited 62 times in Google Scholar. View in Google Scholar

Cited 65 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item