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Low temperature fabrication of biodegradable sugar glass microneedles for transdermal drug delivery applications

Martin, Christopher, Allender, Christopher John, Brain, Keith Roger, Morrissey, A. and Birchall, James Caradoc 2012. Low temperature fabrication of biodegradable sugar glass microneedles for transdermal drug delivery applications. Journal of Controlled Release 158 (1) , pp. 93-101. 10.1016/j.jconrel.2011.10.024

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Abstract

Transdermaldrugdelivery is limited by the barrier properties of the outer skin layer. Microneedles (MNs) effectively circumvent the skin barrier to offer this route as a potential alternative to oral and parenteral delivery of therapeutics. Biodegradablemicroneedles offer particular advantages however processing commonly requires elevated temperatures that may adversely affect heat-labile molecules and macromolecules. In this study, solid amorphous sugarglasses containing low residual quantities of water were created by dehydration of trehalose and sucrose sugar combination solutions. Biodegradablesugarglass MNs were fabricated following optimisation of a simple and novel lowtemperature vacuum deposition micromoulding methodology. These had absolute morphological fidelity to silicon master structures and demonstrated sufficient structural rigidity to efficiently penetrate excised human breast skin. Sugarglass MNs incorporating a marker compound dissolved rapidly and completely in situ releasing dye into deeper skin layers. The biological activity of a model macromolecule was partially retained over extended storage following incorporation into sugarglass. This is the first demonstration that MNs created from amorphous sugarglasses can be used for incorporating and delivering molecules, and potentially biologically active macromolecules, via the transdermal route.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Subjects: R Medicine > RM Therapeutics. Pharmacology
Publisher: Elsevier
ISSN: 0168-3659
Last Modified: 04 Jun 2017 04:05
URI: http://orca-mwe.cf.ac.uk/id/eprint/32378

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