Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Hydroxyureas as Noncovalent Proteasome Inhibitors

Gallastegui, Nerea, Beck, Philipp, Arciniega, Marcelino, Huber, Robert, Hillebrand, Stefan and Groll, Michael 2012. Hydroxyureas as Noncovalent Proteasome Inhibitors. Angewandte Chemie - International Edition 51 (1) , pp. 247-249. 10.1002/anie.201106010

Full text not available from this repository.


Inhibitors with a new mechanism of action are needed for 20S proteasome (CP) inhibition owing to the ineffectiveness of current market drugs against some types of solid tumors. A novel class of nonpeptidic CP inhibitors has been developed, which display reversible and noncovalent binding. The structure-based design of these highly active and site-specific inhibitors revealed unexplored binding subpockets.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > Q Science (General)
Uncontrolled Keywords: hydroxyureas; inhibitors; lipoxygenases; proteasomes; protein crystallography
Publisher: Wiley-Blackwell
ISSN: 1433-7851
Last Modified: 24 Jun 2017 09:33

Citation Data

Cited 27 times in Google Scholar. View in Google Scholar

Cited 45 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item