Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Real-time self-regulation of emotion networks in patients with depression

Linden, David Edmund Johannes ORCID: https://orcid.org/0000-0002-5638-9292, Habes, Isabelle, Johnston, Stephen J., Linden, Stefanie ORCID: https://orcid.org/0000-0003-2120-3811, Tatineni, Ranjit, Subramanian, Leena, Sorger, Bettina, Healy, David Thomas and Goebel, Rainer 2012. Real-time self-regulation of emotion networks in patients with depression. PLoS ONE 7 (6) , e38115. 10.1371/journal.pone.0038115

[thumbnail of Linden 2012.pdf]
Preview
PDF - Published Version
Available under License Creative Commons Attribution.

Download (1MB) | Preview

Abstract

Many patients show no or incomplete responses to current pharmacological or psychological therapies for depression. Here we explored the feasibility of a new brain self-regulation technique that integrates psychological and neurobiological approaches through neurofeedback with functional magnetic resonance imaging (fMRI). In a proof-of-concept study, eight patients with depression learned to upregulate brain areas involved in the generation of positive emotions (such as the ventrolateral prefrontal cortex (VLPFC) and insula) during four neurofeedback sessions. Their clinical symptoms, as assessed with the 17-item Hamilton Rating Scale for Depression (HDRS), improved significantly. A control group that underwent a training procedure with the same cognitive strategies but without neurofeedback did not improve clinically. Randomised blinded clinical trials are now needed to exclude possible placebo effects and to determine whether fMRI-based neurofeedback might become a useful adjunct to current therapies for depression.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Psychology
Neuroscience and Mental Health Research Institute (NMHRI)
Medicine
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RM Therapeutics. Pharmacology
Publisher: PLoS
ISSN: 1932-6203
Date of First Compliant Deposit: 30 March 2016
Last Modified: 08 Jun 2023 09:19
URI: https://orca.cardiff.ac.uk/id/eprint/32050

Citation Data

Cited 268 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics