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The molecular and clinical impact of hepatocyte growth factor, its receptor, activators, and inhibitors in wound healing

Conway, Kevin P., Price, Patricia Elaine, Harding, Keith Gordon and Jiang, Wen Guo 2006. The molecular and clinical impact of hepatocyte growth factor, its receptor, activators, and inhibitors in wound healing. Wound Repair and Regeneration 14 (1) , pp. 2-10. 10.1111/j.1743-6109.2005.00081.x

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Abstract

Wound healing involves a number of cellular and molecular events, many of which are controlled by soluble growth factors. In the process of healing, hepatocyte growth factor, a cytokine known to act as mitogen, motogen, and morphogen, has been postulated to play multiple roles during several stages of this complex biological process. Produced primarily by stromal fibroblasts, hepatocyte growth factor regulates angiogenesis, vascular permeability, cell migration, matrix deposition and degradation, and other biological processes. The current article discusses recent progress in understanding the multiple roles played by this growth factor in tissue repair.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Healthcare Sciences
Subjects: R Medicine > R Medicine (General)
Publisher: Elsevier
ISSN: 1067-1927
Last Modified: 04 Jun 2017 04:00
URI: http://orca-mwe.cf.ac.uk/id/eprint/30640

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