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Emotion processing in schizophrenia: fMRI study of patients treated with risperidone long-acting injections or conventional depot medication

Surguladze, Simon A., Chu, Elvina M., Marshall, Nicolette, Evans, Anthony, Anilkumar, Anantha P. P., Timehin, Clive, McDonald, Colm, Ecker, Christine, Phillips, Mary Louise and David, Anthony S. 2011. Emotion processing in schizophrenia: fMRI study of patients treated with risperidone long-acting injections or conventional depot medication. Journal of Psychopharmacology 25 (6) , pp. 722-733. 10.1177/0269881110363316

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Abstract

We employed two event-related functional magnetic resonance imaging tasks using the pictures of mild and intense facial emotions of fear or happiness. The sample comprised 16 chronic schizophrenia patients treated with risperidone long-acting injections (RLAI), 16 patients treated with conventional antipsychotic depots (CONV) and 16 healthy controls (HC). The HC and RLAI groups demonstrated greater activation in the left amygdala in response to intensively fearful faces, and in right cerebellum to intensively happy faces compared with CONV patients. The CONV group demonstrated under-activation in the right temporal pole in response to intensively happy faces (compared with HC) and over-activation in ventro-medial prefrontal cortex (VMPFC) in response to both intensively happy and fearful expressions, compared with HC and RLAI groups. Our results suggest that networks implicated in the allocation of attentional resources (VMPFC) and emotion processing (amygdala, cerebellum) are differentially affected in patients on CONV versus RLAI.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords: Emotion processing ; fMRI ; Risperidone long acting ; Schizophrenia
Publisher: Sage
ISSN: 0269-8811
Last Modified: 19 Mar 2016 22:53
URI: http://orca-mwe.cf.ac.uk/id/eprint/30225

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