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Pathophysiology of respiratory distress syndrome

Pickerd, Nicole and Kotecha, Sailesh 2009. Pathophysiology of respiratory distress syndrome. Paediatrics and Child Health 19 (4) , pp. 153-157. 10.1016/j.paed.2008.12.010

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Abstract

Respiratory distress syndrome (RDS) is a major cause of neonatal mortality and morbidity, especially in preterm infants. Its aetiology includes developmental immaturity of the lungs, particularly of the surfactant synthesizing system. Surfactant is produced, stored and recycled by type II pneumocytes and is detectable from about 24 weeks’ gestation. It is a mixture of phospholipids, neutral lipids and proteins and is spread as a film over the alveolar surface to lower surface tension and to prevent alveolar collapse. The resulting clinical correlates of RDS can be predicted from the immature lung structure and atelectasis which occur due to surfactant deficiency. Various clinical factors are known to dysregulate surfactant production and function, leading to the development of RDS. Apart from preventing the incidence of prematurity, antenatal steroids and prophylactic surfactant are of proven benefit in reducing the incidence of RDS.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services
Uncontrolled Keywords: alveoli, infant, newborn, preterm birth, pulmonary surfactant, respiratory distress syndrome
Publisher: Elsevier
ISSN: 1751-7222
Last Modified: 12 Jun 2019 02:27
URI: http://orca-mwe.cf.ac.uk/id/eprint/29906

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