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A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia [Letter]

Di Bernardo, Maria Chiara, Crowther-Swanepoel, Dalemari, Broderick, Peter, Webb, Emily, Sellick, Gabrielle, Wild, Ruth, Sullivan, Kate, Vijayakrishnan, Jayaram, Wang, Yufei, Pittman, Alan M, Sunter, Nicola J, Hall, Andrew G, Dyer, Martin J S, Matutes, Estella, Dearden, Claire, Mainou-Fowler, Tryfonia, Jackson, Graham H, Summerfield, Geoffrey, Harris, Robert J, Pettitt, Andrew R, Hillmen, Peter, Allsup, David J, Bailey, James R, Pratt, Guy, Pepper, Christopher John, Fegan, Christopher Daniel, Allan, James M, Catovsky, Daniel and Houlston, Richard S 2008. A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia [Letter]. Nature Genetics 40 (10) , pp. 1204-1210. 10.1038/ng.219

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Abstract

We conducted a genome-wide association study of 299,983 tagging SNPs for chronic lymphocytic leukemia (CLL) and performed validation in two additional series totaling 1,529 cases and 3,115 controls. We identified six previously unreported CLL risk loci at 2q13 (rs17483466; P = 2.36 10-10), 2q37.1 (rs13397985, SP140; P = 5.40 10-10), 6p25.3 (rs872071, IRF4; P = 1.91 10-20), 11q24.1 (rs735665; P = 3.78 10-12), 15q23 (rs7176508; P = 4.54 10-12) and 19q13.32 (rs11083846, PRKD2; P = 3.96 10-9). These data provide the first evidence for the existence of common, low-penetrance susceptibility to a hematological malignancy and new insights into disease causation in CLL.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Publisher: Nature Publishing Group
ISSN: 1061-4036
Last Modified: 04 Jun 2017 03:58
URI: http://orca-mwe.cf.ac.uk/id/eprint/29849

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