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CLEC-2 is a phagocytic activation receptor expressed on murine peripheral blood neutrophils

Kerrigan, Ann M., Dennehy, Kevin M., Mourao-Sa, Diego, Faro-Trindade, Inês, Willment, Janet A., Taylor, Philip Russel, Eble, Johannes A., Reis e Sousa, Caetano and Brown, Gordon D. 2009. CLEC-2 is a phagocytic activation receptor expressed on murine peripheral blood neutrophils. The Journal of Immunology 182 (7) , pp. 4150-4157. 10.4049/jimmunol.0802808

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Abstract

CLEC-2 is a member of the “dectin-1 cluster” of C-type lectin-like receptors and was originally thought to be restricted to platelets. In this study, we demonstrate that murine CLEC-2 is also expressed by peripheral blood neutrophils, but only weakly by bone marrow or elicited inflammatory neutrophils. On circulating neutrophils, CLEC-2 can mediate phagocytosis of Ab-coated beads and the production of proinflammatory cytokines, including TNF-α, in response to the CLEC-2 ligand, rhodocytin. CLEC-2 possesses a tyrosine-based cytoplasmic motif similar to that of dectin-1, and we show using chimeric analyses that the activities of this receptor are dependent on this tyrosine. Like dectin-1, CLEC-2 can recruit the signaling kinase Syk in myeloid cells, however, stimulation of this pathway does not induce the respiratory burst. These data therefore demonstrate that CLEC-2 expression is not restricted to platelets and that it functions as an activation receptor on neutrophils.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: Q Science > QR Microbiology > QR180 Immunology
Publisher: American Association of Immunologists
ISSN: 0022-1767
Last Modified: 04 Jun 2017 03:57
URI: http://orca-mwe.cf.ac.uk/id/eprint/29588

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