Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Clinical and cognitive characteristics of children with attention-deficit hyperactivity disorder, with and without copy number variants

Langley, Kate, Martin, Joanna, Agha, Sharifah Shameem, Davies, Charlotte, Stergiakouli, Evangelia, Holmans, Peter Alan, Williams, Nigel Melville, Owen, Michael John, O'Donovan, Michael Conlon and Thapar, Anita 2011. Clinical and cognitive characteristics of children with attention-deficit hyperactivity disorder, with and without copy number variants. British Journal of Psychiatry 199 (5) , pp. 398-403.

[img]
Preview
PDF - Published Version
Download (394kB) | Preview

Abstract

Background Submicroscopic, rare chromosomal copy number variants (CNVs) contribute to neurodevelopmental disorders but it is not known whether they define atypical clinical cases. Aims To identify whether large, rare CNVs in attention-deficit hyperactivity disorder (ADHD) are confined to a distinct clinical subgroup. Method A total of 567 children with ADHD aged 5–17 years were recruited from community clinics. Psychopathology was assessed using the Child and Adolescent Psychiatric Assessment. Large, rare CNVs (>500 kb, <1% frequency) were defined from single nucleotide polymorphism data. Results Copy number variant carriers (13.6%) showed no differences from non-carriers in ADHD symptom severity, symptom type, comorbidity, developmental features, family history or pre-/perinatal markers. The only significant difference was a higher rate of intellectual disability (24% v. 9%, χ2 = 15.5, P = 0.001). Most CNV carriers did not have intellectual disability. Conclusions Large, rare CNVs are not restricted to an atypical form of ADHD but may be more highly enriched in children with cognitive problems.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Medicine
Systems Immunity Research Institute (SIURI)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
R Medicine > RJ Pediatrics
Publisher: Royal College of Psychiatrists
ISSN: 0007-1250
Date of First Compliant Deposit: 3 January 2018
Last Modified: 08 May 2019 21:31
URI: http://orca-mwe.cf.ac.uk/id/eprint/29174

Citation Data

Cited 13 times in Google Scholar. View in Google Scholar

Cited 17 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics