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Excessive aortic inflammation in chronic obstructive pulmonary disease: an 18F-FDG PET pilot study

Coulson, James Michael, Rudd, James H. F., Duckers, James, Rees, John I. S., Shale, Dennis, Bolton, Charlotte and Cockcroft, John Ronald 2010. Excessive aortic inflammation in chronic obstructive pulmonary disease: an 18F-FDG PET pilot study. Journal of Nuclear Medicine 51 (9) , pp. 1357-1360. 10.2967/jnumed.110.075903

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Abstract

Chronic obstructive pulmonary disease (COPD) patients exhibit increased cardiovascular risk, even after controlling for smoking. Inflammation may underlie this observation. Methods: We measured vascular inflammation in both COPD patients and controls using 18F-FDG PET/CT. Aortic inflammation was expressed as the target-to-background ratio (TBR) of the standardized uptake value in 7 COPD patients, 5 metabolic syndrome patients, and 7 ex-smokers. Results: Abdominal aortic mean TBR (±SD) was greater in COPD patients than in ex-smoker controls (1.60 ± 0.13 vs. 1.34 ± 0.15, P = 0.0001). Aortic arch and abdominal aorta mean TBRs were higher in metabolic syndrome patients than in COPD patients (aortic arch, 1.80 ± 0.18 vs. 1.53 ± 0.18, P = 0.001, and abdominal aorta, 1.71 ± 0.14 vs. 1.60 ± 0.13, P = 0.001). Conclusion: COPD patients exhibited aortic inflammation that fell between the aortic inflammation exhibited by ex-smokers and that by metabolic syndrome patients. This may in part explain the increased risk of cardiovascular disease in COPD patients.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: Imaging, Inflammation, Vessel
Publisher: Society of Nuclear Medicine
ISSN: 0161-5505
Last Modified: 09 Jan 2018 20:17
URI: http://orca-mwe.cf.ac.uk/id/eprint/28852

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