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Stage-specific sampling by pattern recognition receptors during candida albicans phagocytosis

Heinsbroek, Sigrid E. M., Taylor, Philip Russel, Martinez, Fernando O., Martinez-Pomares, Luisa, Brown, Gordon D. and Gordon, Siamon 2008. Stage-specific sampling by pattern recognition receptors during candida albicans phagocytosis. PLoS Pathogens 4 (11) , e1000218. 10.1371/journal.ppat.1000218

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Abstract

Candida albicans is a medically important pathogen, and recognition by innate immune cells is critical for its clearance. Although a number of pattern recognition receptors have been shown to be involved in recognition and phagocytosis of this fungus, the relative role of these receptors has not been formally examined. In this paper, we have investigated the contribution of the mannose receptor, Dectin-1, and complement receptor 3; and we have demonstrated that Dectin-1 is the main non-opsonic receptor involved in fungal uptake. However, both Dectin-1 and complement receptor 3 were found to accumulate at the site of uptake, while mannose receptor accumulated on C. albicans phagosomes at later stages. These results suggest a potential role for MR in phagosome sampling; and, accordingly, MR deficiency led to a reduction in TNF-α and MCP-1 production in response to C. albicans uptake. Our data suggest that pattern recognition receptors sample the fungal phagosome in a sequential fashion.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: Q Science > QR Microbiology > QR180 Immunology
R Medicine > R Medicine (General)
R Medicine > RB Pathology
Publisher: Public Library of Science
ISSN: 1553-7374
Funders: Wellcome Trust, Medical Research Council, EPA Cephalosporin Scholarship, Henry Goodger Scholarship
Date of First Compliant Deposit: 30 March 2016
Last Modified: 04 Jun 2017 03:54
URI: http://orca-mwe.cf.ac.uk/id/eprint/28791

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