The use of remote methods in the conduct of gene-environment interaction studies [Abstract]

Galante, Mariana, Mitchell, Clive Peter, Renfigo, A., Burton, P., Lyons, R. and Gallacher, John Edward ORCID: https://orcid.org/0000-0002-2394-5299 2011. The use of remote methods in the conduct of gene-environment interaction studies [Abstract]. Journal of Epidemiology & Community Health 65 (Supp 1) , A10. 10.1136/jech.2011.142976a.19

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Abstract

Background The scientific value of large-scale prospective geneenvironment interaction (GxE) studies is widely accepted. However, these studies are prohibitively expensive and few are conducted. This approach, therefore, remains under-exploited. The ability to conduct prospective GxE studies entirely remotely, that is, without direct participant contact, promises substantial cost savings and would increase our capacity to utilise this design. Aim To investigate the feasibility of conducting GxE studies entirely remotely by recruiting older people to a pilot study of cognitive function and subjective well-being. Methods A random sample of men and women aged 50+ years and living in Cardiff, South Wales were mailed inviting them to visit a website to join a study of successful ageing. Online consent was obtained for questionnaire completion, cognitive testing, re-contact, record linkage and genotyping. Cognitive testing was conducted using the Cardiff Cognitive Battery. Bio-sampling was randomised to blood spot, buccal cell or no request. Results A heterogeneous sample of 667 men and women (50% female) aged 50e101 years (median¼62 yrs) from diverse backgrounds(representing the full range of deprivation scores) was recruited. Bio-samples were donated by 70% of those agreeing to do so. Self-report questionnaires and cognitive tests showed comparable distributions to those collected using face-to-face methods. Conclusion This study has demonstrated that remote methods can be used to recruit for GxE studies and provides encouragement that up-scaling these methods provides the means to conduct large-scale GxE studies cost-effectively.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Systems Immunity Research Institute (SIURI)
Subjects:	R Medicine > R Medicine (General)
Additional Information:	IEA World Congress of Epidemiology, 7–11 August 2011, Edinburgh International Conference Centre, Edinburgh, Scotland. Abstracts
Publisher:	BMJ Group
ISSN:	0143-005X
Last Modified:	20 Oct 2022 08:31
URI:	https://orca.cardiff.ac.uk/id/eprint/28686

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