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Cerebral and autonomic responses to emotional facial expressions in depersonalisation disorder

Lemche, E., Anilkumar, A., Giampietro, V. P., Brammer, M. J., Surguladze, S. A., Lawrence, N. S., Gasston, D., Chitnis, X., Williams, S. C. R., Sierra, M., Joraschky, P. and Phillips, Mary Louise 2008. Cerebral and autonomic responses to emotional facial expressions in depersonalisation disorder. The British Journal of Psychiatry 193 (3) , pp. 222-228. 10.1192/bjp.bp.107.044263

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Abstract

Background Depersonalisation disorder is characterised by emotion suppression, but the cerebral mechanisms of this symptom are not yet fully understood. Aims To compare brain activation and autonomic responses of individuals with the disorder and healthy controls. Method Happy and sad emotion expressions in increasing intensities (neutral to intense) were presented in an implicit event-related functional magnetic resonance imaging (fMRI) design with simultaneous measurement of autonomic responses. Results Participants with depersonalisation disorder showed fMRI signal decreases, whereas the control group showed signal increases in response to emotion intensity increases in both happy and sad expressions. The analysis of evoked haemodynamic responses from regions exhibiting functional connectivity between central and autonomic nervous systems indicated that in depersonalisation disorder initial modulations of haemodynamic response occurred significantly earlier (2 s post-stimulus) than in the control group (4–6 s post-stimulus). Conclusions The results suggest that fMRI signal decreases are possible correlates of emotion suppression in depersonalisation disorder. © 2008 Royal College of Psychiatrists

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: The Royal College of Psychiatrists
ISSN: 0007-1250
Last Modified: 19 Mar 2016 22:49
URI: http://orca-mwe.cf.ac.uk/id/eprint/28498

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