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BMP-7 stops TGF-β in peritoneal fibrosis

Phillips, Aled Owain and Fraser, Donald James 2010. BMP-7 stops TGF-β in peritoneal fibrosis. Nephrology Dialysis Transplantation 25 (4) , pp. 1036-1038. 10.1093/ndt/gfq032

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Abstract

In this issue, Loureiro, and Cabrera et al. study the regulation of transforming growth factor beta-1 (TGF-β) signalling by bone morphogenetic protein-7 (BMP-7) in the biology of peritoneal dialysis-related peritoneal fibrosis. Peritoneal dialysis (PD) is a highly effective and convenient mode of renal replacement therapy, the success of which depends on the structural and functional integrity of the peritoneal membrane. Progressive alterations in peritoneal membrane transport characteristics commonly cause technique failure in PD, and are associated with fibroproliferative changes in the peritoneal membrane, including vasculopathy, accumulation of submesothelial extracellular matrix, and denudation and altered appearance of mesothelial cells [1]. The fundamental causes of these changes are likely to be long-term exposure to bioincompatible dialysate, together with recurrent episodes of bacterial peritonitis. Fibroproliferative diseases are largely driven by fibroblasts, spindle-shaped, motile, contractile cells that respond to pro-fibrotic stimuli by synthesizing and organizing extracellular matrix. Fibroblasts may originate from proliferation of local tissue fibroblasts, from circulating bone marrow-derived precursors (fibrocytes) and from resident epithelial cells by epithelial-to-mesenchymal transition (EMT) [2]. During EMT, epithelial cells lose intercellular adhesiveness and apical–basal polarity, and acquire a motile and contractile phenotype [3]. High-glucose concentrations typical of peritoneal dialysate induce such phenotypic change in mesothelial cells in vitro [4]. Additionally, the previous work of Cabrera et al. demonstrated progressive loss of epithelial morphology in mesothelial cells

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine
Publisher: Oxford University Press
ISSN: 0931-0509
Last Modified: 08 Oct 2019 03:36
URI: http://orca-mwe.cf.ac.uk/id/eprint/27826

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