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Neuronal death in Alzheimer's disease and therapeutic opportunities

Donev, Rossen Mintchev, Kolev, Martin, Millet, Bruno and Thome, Johannes 2009. Neuronal death in Alzheimer's disease and therapeutic opportunities. Journal of Cellular and Molecular Medicine 13 (11-12) , pp. 4329-4348. 10.1111/j.1582-4934.2009.00889.x

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Abstract

Alzheimer’s disease (AD) is an age-related neurodegenerative disease that affects approximately 24 million people worldwide. A number of different risk factors have been implicated in AD; however, neuritic (amyloid) plaques are considered as one of the defining risk factors and pathological hallmarks of the disease. In the past decade, enormous efforts have been devoted to understand the genetics and molecular pathogenesis leading to neuronal death in AD, which has been transferred into extensive experimental approaches aimed at reversing disease progression. Modern medicine is facing an increasing number of treatments available for vascular and neurodegenerative brain diseases, but no causal or neuroprotective treatment has yet been established. Almost all neurological conditions are characterized by progressive neuronal dysfunction, which, regardless of the pathogenetic mechanism, finally leads to neuronal death. The particular emphasis of this review is on risk factors and mechanisms resulting in neuronal loss in AD and current and prospective opportunities for therapeutic interventions. This review discusses these issues with a view to inspiring the development of new agents that could be useful for the treatment of AD.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: Alzheimer’s disease ; neuronal death ; neurodegeneration ; neurotoxicity ; neuroprotection ; amyloid plaques
Additional Information: Pdf uploaded in accordance with publisher's policy at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1582-4934/homepage/open_access_license_and_copyright.htm (accessed 24/04/2014).
Publisher: Carol Davila University Press
ISSN: 1582-1838
Date of First Compliant Deposit: 30 March 2016
Last Modified: 09 Jan 2018 19:45
URI: http://orca-mwe.cf.ac.uk/id/eprint/27587

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