Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Challenges in the genetic testing of children for familial cancers

Clarke, Angus John and Gaff, Clara Louise 2008. Challenges in the genetic testing of children for familial cancers. Archives of Disease in Childhood 93 (11) , pp. 911-914. 10.1136/adc.2006.113381

Full text not available from this repository.

Abstract

The genetic testing of children is a topic that has generated much disagreement and debate. When a child has an illness that may be genetic in origin, and genetic testing is a straightforward way of achieving a diagnosis, then genetic testing is clearly appropriate. When the child is healthy but at risk of the family’s inherited disorder, however, the situation may be very different. In cases where predictive genetic information is of clear practical value in decision making about future medical intervention, then the question comes down to a matter of timing: when, all things considered, will it be most helpful to determine the child’s genetic constitution? Internationally, guidelines encourage decisions about testing be left to the child once s/he is older if no medical intervention is available during childhood and adolescence for those at risk of disease.1 Nonetheless, in clinical practice, counselling parents who are seeking predictive genetic testing of their child for an adult onset condition is often more complex than simply citing guidelines as a reason for declining testing and expecting the family to deal with the consequences. These requests can raise complex issues for health professionals, bringing into play potentially conflicting commitments of genetics professionals, such as client-centred counselling (with the family as client), providing advocacy (for the child) and the need to consider the professionals’ long term relationship with the family. Here we discuss four scenarios that exemplify issues that arise not infrequently in practice. We have altered some case details to ensure anonymity.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services
Publisher: BMJ Publishing Group
ISSN: 0003-9888
Last Modified: 04 Jun 2017 03:49
URI: http://orca-mwe.cf.ac.uk/id/eprint/27563

Citation Data

Cited 15 times in Google Scholar. View in Google Scholar

Cited 13 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item