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Proceedings of the International Consensus Conference on Breast Cancer Risk, Genetics, & Risk Management, April, 2007

Schwartz, Gordon F., Hughes, Kevin S., Lynch, Henry T., Fabian, Carol J., Fentiman, Ian S., Robson, Mark E., Domchek, Susan M., Hartmann, Lynn C., Holland, Roland, Winchester, David J. and Mansel, Robert Edward 2009. Proceedings of the International Consensus Conference on Breast Cancer Risk, Genetics, & Risk Management, April, 2007. The Breast Journal 15 (1) , pp. 4-16. 10.1111/j.1524-4741.2008.00665.x

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Abstract

Abstract: A consensus conference including thirty experts was held in April, 2007, to discuss risk factors for breast cancer and their management. Four categories of risk were outlined, from breast cancer ‘‘average’’ through ‘‘very high’’ risk, the latter including individuals with high penetrance BRCA1⁄ 2 gene mutations. Guidelines for management of patients in each of these categories were discussed, with the major portion of the conference being devoted to individuals with BRCA1⁄ 2 mutations. Prevalence of these mutations in the general populations was estimated to be 1 in 250–500 individuals, with an increased prevalence in Ashkenazic Jews and other founder groups. Risk reduction strategies for these individuals include surveillance, with or without chemoprevention drugs, or surgical procedures to remove the organs at risk, i.e., bilateral mastectomy and ⁄ or bilateral salpingo-oophorectomy. These risk reduction strategies were evaluated fully, and recommendations were made for the care of patients in each of the risk categories. These guidelines for patient care were approved by the entire group of experts.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: Q Science > QH Natural history > QH426 Genetics
R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Uncontrolled Keywords: BRCA; breast cancer; genetics; risk
Publisher: Wiley
ISSN: 1075-122X
Last Modified: 04 Jun 2017 03:49
URI: http://orca-mwe.cf.ac.uk/id/eprint/27373

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