The effect of onset age on the clinical features of Parkinson's disease

Wickremaratchi, Mirdhu, Ben-Shlomo, Y. and Morris, Huw Rees 2009. The effect of onset age on the clinical features of Parkinson's disease. European Journal of Neurology 16 (4) , pp. 450-456. 10.1111/j.1468-1331.2008.02514.x

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Abstract

Many clinicians view age at onset as an important determinant of clinical phenotype in Parkinson’s disease (PD) and this has been reinforced by the identification of Mendelian genes that account for some cases of younger onset PD. A systematic review of OVID Medline for articles relevant to the relationship between clinical features and age at onset in PD published in English between 1950–2007 was performed. There are very few prospective community based studies which focus on the relationship between age at onset and the features of PD and a variety of case definitions are used in the literature. Most studies of young onset PD are based on specialist clinic referral series. The available evidence suggests that PD patients with a younger age at onset have: (i) a slower disease progression, (ii) an increased rate of dystonia at onset and during treatment, (iii) a lower rate of dementia and (iv) an increased rate of dyskinesias in response to l-DOPA treatment. The majority of the available studies do not report patient genotype data, but it is probably that the clinical heterogeneity of PD will be further refined with detailed clinico-genetic studies.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	dyskinesias, Parkinson’s disease, treatment response, young-onset Parkinson’s disease
Publisher:	Wiley
ISSN:	1351-5101
Last Modified:	10 Oct 2017 14:14
URI:	https://orca.cardiff.ac.uk/id/eprint/27115

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