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Fibroblasts and myofibroblasts in renal fibrosis

Meran, Soma and Steadman, Robert 2011. Fibroblasts and myofibroblasts in renal fibrosis. International Journal of Experimental Pathology 92 (3) , pp. 158-167. 10.1111/j.1365-2613.2011.00764.x

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Abstract

Interstitial fibrosis, associated with extensive accumulation of extracellular matrix constituents in the cortical interstitium, is directly correlated to progression of renal disease. The earliest histological marker of this progression is the accumulation in the interstitium of fibroblasts with the phenotypic appearance of myofibroblasts. These myofibroblasts are contractile cells that express alpha smooth muscle actin and incorporate it into intracellular stress fibres. Although fibroblasts are histologically visible in normal kidneys, there are relatively few of them and proximal tubular epithelial cells predominate. In progressive disease, however, the interstitium becomes filled with myofibroblasts. In this review, we will examine the phenotype and function of fibroblasts and myofibroblasts in the cortical interstitium and the processes that may modulate them.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Uncontrolled Keywords: differentiation, EMT, extracellular matrix, fibroblast, fibrocyte, hyaluronan, myofibroblast
Publisher: Blackwell Publishing
ISSN: 0959-9673
Last Modified: 07 May 2019 19:53
URI: http://orca-mwe.cf.ac.uk/id/eprint/26506

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