Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Beta2-microglobulin is a better predictor of treatment-free survival in patients with chronic lymphocytic leukaemia if adjusted according to glomerular filtration rate

Delgado, Julio, Pratt, Guy, Phillips, Neil, Briones, Javier, Fegan, Christopher Daniel, Nomdedeu, Josep, Pepper, Christopher John, Aventin, Anna, Ayats, Ramon, Brunet, Salut, Martino, Rodrigo, Valcarcel, David, Milligan, Donald and Sierra, Jorge 2009. Beta2-microglobulin is a better predictor of treatment-free survival in patients with chronic lymphocytic leukaemia if adjusted according to glomerular filtration rate. British Journal of Haematology 145 (6) , pp. 801-805. 10.1111/j.1365-2141.2009.07699.x

Full text not available from this repository.

Abstract

Even in the era of newer and sophisticated prognostic markers, beta2- microglobulin (B2M) remains a simple but very powerful predictor of treatment-free survival (TFS) and overall survival (OS) in patients with chronic lymphocytic leukaemia (CLL). However, B2M levels are heavily influenced by the patient’s glomerular filtration rate (GFR) and this study aimed to evaluate whether GFR-adjusted B2M (GFR-B2M) had improved prognostic value compared to unadjusted B2M in a cohort of over 450 consecutive CLL patients from two separate institutions. Multivariate analysis identified a significantly shorter TFS in patients who were ZAP- 70 + (P < 0Æ001), with increased GFR-B2M (P < 0Æ001), and del(11q) or del(17p) as detected by fluorescence in situ hybridization (FISH; P < 0Æ001). When OS was evaluated by multivariate analysis, age 65 years or older (P < 0Æ001) and poor risk FISH abnormalities (P < 0Æ001) had a confirmed adverse prognostic impact, but the predictive value of GFR-B2M was lost in the validation analysis. In all survival models, B2M did not attain independent significance unless GFR-B2M was eliminated from the analysis. In conclusion, GFR-B2M is a better predictor of TFS than unadjusted B2M in CLL patients.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Uncontrolled Keywords: beta2-microglobulin, glomerular filtration rate, chronic lymphocytic leukaemia
Publisher: Wiley-Blackwell
ISSN: 0007-1048
Last Modified: 04 Jun 2017 03:46
URI: http://orca-mwe.cf.ac.uk/id/eprint/26180

Citation Data

Cited 28 times in Google Scholar. View in Google Scholar

Cited 33 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item