Depression is associated with increased sensitivity to signals of disgust: a functional magnetic resonance imaging study

Surguladze, Simon A., El-Hage, Wissam, Dalgleish, Tim, Radua, Joaquim, Gohier, Benedicte and Phillips, Mary Louise 2010. Depression is associated with increased sensitivity to signals of disgust: a functional magnetic resonance imaging study. Journal of Psychiatric Research 44 (14) , pp. 894-902. 10.1016/j.jpsychires.2010.02.010

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Abstract

Emotions of fear and disgust are related to core symptoms of depression. The neurobiological mechanisms of these associations are poorly understood. This functional magnetic resonance imaging study aimed at examining the Blood oxygenation level dependent (BOLD) response to facial expressions of fear and disgust in patients with major depressive disorder. Nine patients in an episode of major depression and nine healthy controls underwent two functional magnetic resonance imaging experiments where they judged the gender of facial identities displaying different degrees (mild, strong) of fear or disgust, intermixed with non-emotional faces. Compared with healthy controls, patients with depression demonstrated greater activation in left insula, left orbito-frontal gyrus, left middle/inferior temporal gyrus, and right middle/inferior temporal gyrus to expressions of strong disgust. Depressed patients also demonstrated reduced activation in left inferior parietal lobe to mildly fearful faces. Enhanced activation to facial expressions of disgust may reflect an emotion processing bias that suggests high relevance of emotion of disgust to depression.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	depression, fMRI, fear, disgust
Publisher:	Elsevier
ISSN:	0022-3956
Last Modified:	19 Mar 2016 22:45
URI:	https://orca.cardiff.ac.uk/id/eprint/26031

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