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The role of complement and complement regulators in mediating motor nerve terminal injury in murine models of Guillain-Barré syndrome

Willison, Hugh J., Halstead, Susan K., Beveridge, Erin, Zitman, Femke M. P., Greenshields, Kay N., Morgan, Bryan Paul and Plomp, Jaap J. 2008. The role of complement and complement regulators in mediating motor nerve terminal injury in murine models of Guillain-Barré syndrome. Journal of Neuroimmunology 201 , pp. 172-182. 10.1016/j.jneuroim.2008.05.028

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Abstract

Recent research into the Guillain–Barré syndromes (GBS) has focused on anti-ganglioside antibodies that correlate with specific clinical phenotypes. Our increasing understanding of the role of antibodies in mediating GBS has naturally focused our attention on complement involvement in the pathological procession. We have studied the axonal and glial components of the murine motor nerve terminal as a model site of antibody and complement mediated injury. Such studies are providing us with clear information on the molecular components underlying our clinicopathological model for GBS and have lead us to the testing of emerging complement therapeutics that are potentially suitable for human use.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: ganglioside, antibody, complement, Guillain–Barré syndrome, Miller Fisher syndrome, motor nerve terminal
Publisher: Elsevier
ISSN: 0165-5728
Last Modified: 04 Jun 2017 03:45
URI: http://orca-mwe.cf.ac.uk/id/eprint/26023

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