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The contribution of naturally occurring IgM antibodies, IgM cross-reactivity and complement dependency in murine humoral responses to pneumococcal capsular polysaccharides

Jones, Hannah E., Taylor, Philip Russel, McGreal, Eamon Patrick, Zamze, Susanne and Wong, Simon Y. C. 2009. The contribution of naturally occurring IgM antibodies, IgM cross-reactivity and complement dependency in murine humoral responses to pneumococcal capsular polysaccharides. Vaccine 27 (42) , pp. 5806-5815. 10.1016/j.vaccine.2009.07.063

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Abstract

Immunogenicity of 12 capsular polysaccharides (CPS) from Streptococcus pneumoniae did not correlate with pre-existing levels of natural IgM anti-CPS antibodies in mice. Immunization of mice with individual CPS, with the exception of type 14 (the only neutral CPS tested), increased serum IgM that also bound other CPS serotypes independent of structural similarity or commonly known contaminants. Surprisingly only IgM response to type 4 (which has a small immunodominant epitope) was dependent on either complement C3 or complement receptors CD35/CD21. IgG anti-CPS responseswere infrequently induced, but critically dependentoncomplement. Our resultshave clarifiedthe role ofcomplement in the induction of IgM and IgG anti-CPS antibody responses in mice and have implications for CPS vaccine development.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: Complement; Antibodies; Polysaccharide vaccines
Publisher: Elsevier
ISSN: 0264-410X
Last Modified: 04 Jun 2017 03:44
URI: http://orca-mwe.cf.ac.uk/id/eprint/25648

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