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Arterial wave intensity and ventricular-arterial coupling by vascular ultrasound: rationale and methods for the automated analysis of forwards and backwards running waves

Rakebrandt, Frank, Palombo, C., Swampillai, Janice, Schön, F., Donald, A., Kozàkovà, M., Kato, K. and Fraser, Alan Gordon 2009. Arterial wave intensity and ventricular-arterial coupling by vascular ultrasound: rationale and methods for the automated analysis of forwards and backwards running waves. Ultrasound in Medicine & Biology 35 (2) , pp. 266-277. 10.1016/j.ultrasmedbio.2008.08.013

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Abstract

Wave intensity (WI) in the circulation is estimated noninvasively as the product of instantaneous changes in pressure and velocity. We recorded diameter as a surrogate for pressure, and velocity in the right common carotid artery using an Aloka SSD-5500 ultrasound scanner. We developed automated software, applying the water hammer equation to obtain local wave speed from the slope of a pressure/velocity loop during early systole to separate net WI into individual forwards and backwards-running waves. A quality index was developed to test for noisy data. The timing, duration, peak amplitude and net energy of separated WI components were measured in healthy subjects with a wide age range. Age and arterial stiffness were independent predictors of local wave speed, whereas backwards-travelling waves correlated more strongly with ventricular systolic function than with age-related changes in arterial stiffness. Separated WI offers detailed insight into ventricular-arterial interactions that may be useful for assessing the relative contributions of ventricular and vascular function to wave travel.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Optometry and Vision Sciences
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: Wave intensity; Wave reflection; Arterial stiffness; Cardiovascular ultrasound; Quality control
Publisher: Elsevier
ISSN: 0301-5629
Last Modified: 04 Jun 2017 03:44
URI: http://orca-mwe.cf.ac.uk/id/eprint/25599

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