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Beneficial effect of anti-interleukin-4 antibody when administered in a murine model of tuberculosis infection

Roy, Eleanor, Brennan, John, Jolles, Stephen and Lowrie, Douglas Bruce 2008. Beneficial effect of anti-interleukin-4 antibody when administered in a murine model of tuberculosis infection. Tuberculosis 88 (3) , pp. 197-202. 10.1016/j.tube.2007.11.005

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Abstract

There remains much controversy surrounding the role of Th2 cytokines, such as interleukin-4 (IL-4), in tuberculosis infection. Here we demonstrate that anti-IL-4 antibody, administered as a pulse during the early or late stages of murine infection, can provide significant reductions in the bacterial burden. The fact that substantial benefit can be achieved when treatment is administered during established infection strengthens the view that clinical interventions aimed at suppressing the IL-4 component of the host immune response seen in tuberculosis patients may be beneficial.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: Q Science > QR Microbiology
R Medicine > R Medicine (General)
Uncontrolled Keywords: Murine tuberculosis; Immunotherapy; Anti-IL-4; Anti-IL-13
Publisher: Elsevier
ISSN: 1472-9792
Last Modified: 04 Jun 2017 03:44
URI: http://orca-mwe.cf.ac.uk/id/eprint/25591

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