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The mouse complement regulator CD59b is significantly expressed only in testis and plays roles in sperm acrosome activation and motility

Donev, Rossen Mintchev, Baalasubramanian, Sivasankar, Mizuno, Masashi and Morgan, Bryan Paul 2008. The mouse complement regulator CD59b is significantly expressed only in testis and plays roles in sperm acrosome activation and motility. Molecular Immunology 45 (2) , pp. 534-542. 10.1016/j.molimm.2007.05.011

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Abstract

In mouse, genes encoding complement regulators CD55 and CD59 have been duplicated. The first described form of CD59, CD59a, is broadly distributed in mouse tissues, while the later identified CD59b was originally described as testis specific. Subsequent studies have been contradictory, some reporting widespread and abundant expression of CD59b. Resolution of the distribution patterns of the CD59 isoforms is important for interpretation of disease studies utilising CD59 knockout mice. Here we have performed a comprehensive distribution study of the CD59 isoforms at the mRNA and protein levels. These data confirm that expression of CD59b is essentially restricted to adult testis; trace expression in other tissues is a consequence of contamination with blood cells, shown previously to express CD59b at low level. In testis, onset of expression of CD59b coincided with puberty and was predominant on the spermatozoal acrosome. Ligation of CD59b, but not CD59a, markedly reduced spermatozoal motility, suggesting a specific role in reproductive function.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: Mouse; CD59a; CD59b; Complement; Reproductive immunology; Acrosome
Publisher: Elsevier
ISSN: 0161-5890
Last Modified: 07 Feb 2019 21:37
URI: http://orca-mwe.cf.ac.uk/id/eprint/25498

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