Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Protein quality control in the bacterial periplasm

Merdanovic, Melisa, Clausen, Tim, Kaiser, Markus, Huber, Robert and Ehrmann, Michael 2011. Protein quality control in the bacterial periplasm. Annual Review of Microbiology 65 (1) , pp. 149-168. 10.1146/annurev-micro-090110-102925

Full text not available from this repository.

Abstract

Protein quality control involves sensing and treatment of defective or incomplete protein structures. Misfolded or mislocalized proteins trigger dedicated signal transduction cascades that upregulate the production of protein quality-control factors. Corresponding proteases and chaperones either degrade or repair damaged proteins, thereby reducing the level of aggregation-prone molecules. Because the periplasm of gram-negative bacteria is particularly exposed to environmental changes and respective protein-folding stresses connected with the presence of detergents, low or high osmolarity of the medium, elevated temperatures, and the host's immune response, fine-tuned protein quality control systems are essential for survival under these unfavorable conditions. This review discusses recent advances in the identification and characterization of the key cellular factors and the emerging general principles of the underlying molecular mechanisms.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > Q Science (General)
Publisher: Annual Reviews
ISSN: 0066-4227
Last Modified: 24 Jun 2017 08:58
URI: http://orca-mwe.cf.ac.uk/id/eprint/25269

Citation Data

Cited 55 times in Google Scholar. View in Google Scholar

Cited 97 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item