Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Carbon monoxide: an emerging regulator of ion channels

Wilkinson, William James and Kemp, Paul J. 2011. Carbon monoxide: an emerging regulator of ion channels. The Journal of Physiology 589 (13) , pp. 3055-3062. 10.1113/jphysiol.2011.206706

Full text not available from this repository.

Abstract

Carbon monoxide is rapidly emerging as an important cellular messenger, regulating a wide range of physiological processes. Crucial to its role in both physiology and disease is its ability differentially to regulate several classes of ion channels, including examples from calcium-activated K+ (BKCa), voltage-activated K+ (Kv) and Ca2+ channel (L-type) families, ligand-gated P2X receptors (P2X2 and P2X4), tandem P domain K+ channels (TREK1) and the epithelial Na+ channel (ENaC). The mechanisms by which CO regulates these ion channels are still unclear and remain somewhat controversial. However, available structure–function studies suggest that a limited range of amino acid residues confer CO sensitivity, either directly or indirectly, to particular ion channels and that cellular redox state appears to be important to the final integrated response. Whatever the molecular mechanism by which CO regulates ion channels, endogenous production of this gasotransmitter has physiologically important roles and is currently being explored as a potential therapeutic.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > Q Science (General)
Publisher: The Physiological Society
ISSN: 0022-3751
Last Modified: 04 Jun 2017 03:42
URI: http://orca-mwe.cf.ac.uk/id/eprint/25212

Citation Data

Cited 47 times in Google Scholar. View in Google Scholar

Cited 72 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item