FKBP12.6 binding of ryanodine receptors carrying mutations associated with arrhythmogenic cardiac disease

Zissimopoulos, Spryos, Thomas, Nia Lowri, Jamaluddin, Wan W. and Lai, Francis Anthony 2009. FKBP12.6 binding of ryanodine receptors carrying mutations associated with arrhythmogenic cardiac disease. Biochemical Journal 419 (2) , pp. 273-278. 10.1042/BJ20082324

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Abstract

In the present paper we show that distinct human RyR2 (ryanodine receptor type 2) inherited mutations expressed in mammalian cells exhibit either unaltered or increased FKBP12.6 (12.6 kDa FK506-binding protein) binding compared with the wild-type. Oxidizing conditions result in decreased FKBP12.6 binding, but to the same extent as for the wild-type. Our findings suggest that FKBP12.6 regulation of RyR2 is unlikely to be the primary defect in inherited arrhythmogenic cardiac disease.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > RG Gynecology and obstetrics
Uncontrolled Keywords:	arrhythmogenic cardiac disease; FKBP12.6; immunophilin, protein interaction; redox regulation; ryanodine receptor
Publisher:	Biochemical Society
ISSN:	0264-6021
Last Modified:	27 Mar 2020 02:37
URI:	http://orca-mwe.cf.ac.uk/id/eprint/25130

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